Is the use of Finasteride recommended in women?

There are many rumors and comments that circulate in advertisements, magazines, forums and of course in the daily word of mouth about the use of finasteride in women . Next, we will clarify this matter.

Hair is of great importance to humans and its loss is one of the inesthetics that most worries those who suffer from it. In the history of humanity it is a problem that has always existed because hair is considered a symbol of beauty and sexual attractiveness.

Hair loss is more common in men than in women, but as a general rule it affects women more psychologically, even with minimal degrees of alopecia, according to American and Spanish studies.

The androgenetic alopecia female (sometimes we talk about female pattern alopecia) is the most common form of falling hair and affects more than 50% of women throughout their lives and their prevalence and severity increase with age .

It is characterized, like androgenetic alopecia in man, by a progressive miniaturization of the hair follicles, with shortening of the anagen or growth phase and prolongation of the telogen or resting phase. In the same way as in men, the enzyme 5-alpha reductase, which acts in the conversion of testosterone into dihydrotestosterone (DHT), plays a determining role in this process.

The different clinical patterns in women are believed to be due to the difference in the levels and distribution of 5-alpha reductase, aromatase, and androgen receptors in hair follicles.

Therefore, apart from the administration of Minoxidil topically, which is usually quite effective, although sometimes not well accepted by patients, the use of oral antiandrogens appears as a treatment to consider also in women. Thus, cyproterone acetate, spironolactone, flutamide, finasteride … appear on the horizon of possible alternatives in terms of medical treatments.

Is the use of Finasteride recommended in women?

The Finasteride is a peripheral antiandrogen. Its action as a synthetic azasteroid compound focuses on treating the pathophysiology of the hair loss process by inhibiting the type II 5-alpha reductase enzyme. Although it has been shown to be effective at a dose of 1 mg / day to treat male androgenetic alopecia, its efficacy in women is more controversial .

-Its use is contraindicated in women of childbearing age , since in case of pregnancy it can cause malformations in the external genitalia of the male fetus. It is recommended that pregnant women do not handle the tablets due to the risk of possible percutaneous absorption.

-If it is used in premenopausal women, it must be administered together with anovulatory drugs because it could cause a feminization of the male fetus.

-In postmenopausal women it can be used although the recommended dose is 2.5 mg / day.

Regarding the results, it seems to be an effective treatment in women when there are androgenic implications in its etiopathogenesis.

From this point of view, many authors accept that women with early-onset alopecia and clinical hyperandrogenism respond better and that the later the onset of alopecia, the worse the response tends to be, since hair thinning does not depend so much on the androgens as well as other factors.

Finally, we believe that it is very important to clarify in this finasteride-woman relationship that finasteride has not been shown to cause sterility , so it is not necessary to suspend it to achieve pregnancy. Nor has a risk of fetal malformations been demonstrated during pregnancy as long as it is taken by the man, since the amount of finasteride eliminated by semen is so small that it does not produce alterations.

In any case, for the couple’s psychological reassurance, a condom can be used during these months.

In this and other topics related to your health, the source of information is essential to know the truth. Therefore, do not be left with any doubt or insecurity, always put yourself in the hands of professionals!

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